MYELOID NEOPLASIA Effect of the nonpeptide thrombopoietin receptor agonist Eltrombopag on bone marrow cells from patients with acute myeloid leukemia and myelodysplastic syndrome
نویسندگان
چکیده
1Department of Cell Biology and Albert Einstein Cancer Center, Albert Einstein College of Medicine, Bronx, NY; 2Department of Hematology, Oncology, and Clinical Immunology, Heinrich Heine University, Duesseldorf, Germany; 3Department of Medicine, Albert Einstein College of Medicine, Bronx, NY; 4GlaxoSmithKline, Collegeville, PA; and 5Department of Developmental and Molecular Biology, Albert Einstein College of Medicine, Bronx, NY
منابع مشابه
Effect of the nonpeptide thrombopoietin receptor agonist Eltrombopag on bone marrow cells from patients with acute myeloid leukemia and myelodysplastic syndrome.
Thrombocytopenia is a frequent symptom and clinical challenge in patients with myelodysplastic syndrome (MDS) and acute myeloid leukemia (AML). Eltrombopag is a small molecule thrombopoietin receptor agonist that might be a new option to treat thrombocytopenia in these diseases, provided that it does not stimulate malignant hematopoiesis. In this work, we studied the effects of Eltrombopag on p...
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